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Chemically revised conducting polymers with inflammation resistance for intimate bioelectronic electrocoupling
Sihao Qian1,2, Hsing-An Lin2, Qichao Pan2
1State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, China.
Bioactive Materials
|March 6, 2023
Summary
Chemically revised conducting polymers offer solutions for long-term bioelectronic implants by improving tissue integration and electrochemical performance. Zwitterionic conducting polymers show promise for stable, selective neural coupling in vivo.
Area of Science:
- Biomaterials science
- Neuroscience
- Polymer chemistry
Background:
- Conducting polymers possess unique properties like mixed ionic-electronic conductivity, tunable interfaces, and tissue compatibility, making them suitable for brain-computer interfaces.
- Current bioelectronic implants face challenges including chronic immune responses, poor neuron attraction, and unstable long-term electrocommunication.
Purpose of the Study:
- This review focuses on chemically revised conducting polymers for advanced bioelectronic implants.
- It highlights the progress of zwitterionic conducting polymers for stable, long-term in vivo applications.
- The review aims to provide a forward look at future developments in zwitterionic conducting polymers for neural devices.
Main Methods:
- Review of literature on chemically revised and zwitterionic conducting polymers for bioelectronic applications.
- Analysis of electrochemical performance and biocompatibility data.
- Discussion of strategies to overcome challenges in neural interfacing.
Main Results:
- Chemically revised conducting polymers demonstrate improved electrochemical performance and stability for long-term implantation.
- Zwitterionic conducting polymers have achieved stable implantation for over 4 weeks.
- Advancements in zwitterionic polymers are enabling selective neural coupling and reimplantable functions.
Conclusions:
- Chemically revised conducting polymers are robust candidates for bridging the gap between brain tissue and electronic circuits.
- Zwitterionic conducting polymers represent a significant advancement in bioelectronic implant technology.
- Future research should focus on optimizing zwitterionic polymers for selective neural coupling and in vivo functionality.
