Related Experiment Video
Updated: Aug 8, 2025
07:23
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
508
The Interplay between Noncoding RNAs and p21 Signaling in Gastrointestinal Cancer: From Tumorigenesis to Metastasis
Farzad Rahmani1,2,3, Mehrdad Zandigohar4, Pegah Safavi5
1Department of Clinical Biochemistry, Kashmar School of Nursing, Mashhad University of Medical Sciences, Mashhad, Iran.
Current Pharmaceutical Design
|March 6, 2023
Summary
Non-coding RNAs (ncRNAs) regulate the cell cycle protein p21, impacting gastrointestinal cancer. Understanding these ncRNA-p21 interactions may reveal new therapeutic targets for GI cancers.
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Non-coding RNAs (ncRNAs) are key regulators in cancer, influencing cell cycle progression, proliferation, and invasion.
- The cell cycle regulator p21 plays a dual role (tumor-suppressive or oncogenic) in cancer, affecting DNA damage response, growth, and metastasis.
- p21 modulates cell cycle checkpoints (G1/S and G2/M) by interacting with cyclin-dependent kinases (CDKs) and proliferating cell nuclear antigen (PCNA).
Purpose of the Study:
- To review the mechanisms by which microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) regulate p21 signaling.
- To explore the impact of ncRNA-mediated p21 regulation on gastrointestinal (GI) tumorigenesis.
- To highlight the potential of targeting the ncRNA-p21 axis for novel GI cancer therapies.
Main Methods:
- Literature review of studies on ncRNAs, p21, and GI cancer.
- Analysis of transcriptional and post-transcriptional regulation of p21 by ncRNAs.
- Examination of p21's role in cell cycle control and DNA damage response.
Main Results:
- ncRNAs, including miRNAs and lncRNAs, significantly regulate p21 expression and function.
- Dysregulation of the ncRNA-p21 axis is implicated in the initiation and progression of GI cancers.
- p21's complex roles in cell cycle arrest, DNA repair, and apoptosis are modulated by specific ncRNAs.
Conclusions:
- ncRNAs are critical players in modulating p21's function in the context of GI cancer.
- Targeting specific ncRNA-p21 interactions presents a promising avenue for developing novel therapeutic strategies.
- Further research into ncRNA-p21 pathways could uncover new biomarkers and treatments for gastrointestinal malignancies.
More Related Videos
13:18Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
1.3K
10:32Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
Published on: December 19, 2019
11.0K
Related Concept Videos
01:19Interactions Between Signaling Pathways
6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
02:39lncRNA - Long Non-coding RNAs
8.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.7K
03:03mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
01:41Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.6K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.6K