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Related Experiment Video

Updated: Aug 8, 2025

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

Correlation Between Retinal Vessel Diameters and Uveitis Activity.

Federico Zicarelli¹, Aniruddha Agarwal^2,3, Chiara Rizzi¹

¹Eye Clinic, Department of Biomedical and Clinical Science, Luigi Sacco Hospital, University of Milan, Milan, Italy.

Investigative Ophthalmology & Visual Science

|March 6, 2023

Summary

This summary is machine-generated.

Retinal vein and artery diameters increase during active uveitis and decrease as inflammation resolves. These changes in central retina vein equivalent (CRVE) and central retina artery equivalent (CRAE) are linked to inflammation status.

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Area of Science:

Ophthalmology
Retinal Vascular Diseases
Uveitis Research

Background:

Intraocular inflammation in uveitis can affect retinal vasculature.
Understanding changes in retinal vessel diameters is crucial for disease monitoring.

Purpose of the Study:

To assess changes in retinal vein and artery diameters during active and inactive intraocular inflammation in uveitis patients.
To investigate the correlation between these vascular changes and clinical factors.

Main Methods:

Retrospective analysis of color fundus photographs from 89 eyes with uveitis at active (T0) and inactive (T1) stages.
Semi-automated analysis to measure central retina vein equivalent (CRVE) and central retina artery equivalent (CRAE).
Statistical analysis to determine changes in CRVE and CRAE and their correlation with clinical data.

Main Results:

Both CRVE and CRAE significantly reduced from active to inactive stages (P < 0.0001 and P = 0.01).
Active inflammation was a significant factor influencing both CRVE and CRAE (P < 0.0001 and P = 0.0004).
Venular and arteriolar dilation was influenced by time, and visual acuity by time and ethnicity.

Conclusions:

Central retina vein equivalent (CRVE) and central retina artery equivalent (CRAE) are elevated during active intraocular inflammation in uveitis.
These retinal vascular parameters decrease as inflammation subsides.
Findings highlight the dynamic impact of inflammation on retinal vasculature in uveitis.