Pro-and Antioxidant Status in Newborn with COVID-19.

Area of Science:

• Neonatal Medicine
• Infectious Diseases
• Biochemistry

Background:

• Limited data exists on oxidative stress in newborns with COVID-19.
• Understanding neonatal reactivity to infections is crucial for different age groups.
• COVID-19 poses risks to newborns, necessitating further investigation.

Purpose of the Study:

• To assess pro- and antioxidant status indicators in newborns with confirmed COVID-19.
• To investigate the impact of coronavirus infection on neonatal oxidative stress.
• To contribute to a better understanding of COVID-19's effects on infant metabolism.

Main Methods:

• Studied 44 newborns diagnosed with COVID-19.
• Measured levels of lipid peroxidation (LPO) products.
• Assessed activity of superoxide dismutase (SOD) and glutathione peroxidase, and retinol levels.

Main Results:

• Elevated levels of unsaturated double bond compounds, primary, secondary, and final LPO products were observed.
• Increased SOD activity and retinol levels were noted.
• Reduced glutathione peroxidase activity was found in infected newborns.

Conclusions:

• Newborns demonstrate significant oxidative stress during COVID-19 infection.
• These metabolic changes suggest newborns are a susceptible population to COVID-19.
• Close monitoring of metabolic reactions during neonatal adaptation is essential for infected infants.