Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multicompartment Models: Overview01:14

Multicompartment Models: Overview

205
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
205
Steady State Concentration01:05

Steady State Concentration

4.6K
A steady state refers to the level of a drug in the body once it has reached an equilibrium between administration and elimination. It represents the point at which the drug administration rate equals the drug elimination rate, resulting in a relatively constant concentration in the body over time. The dynamic equilibrium is crucial to ensure the drug's effectiveness with minimal risk of toxicity.
Most drugs are administered in repeated doses at fixed intervals or through continuous...
4.6K
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

230
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
230
Three-Compartment Open Model01:06

Three-Compartment Open Model

321
The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
321
Biopharmaceutics and Pharmacokinetics: Overview01:28

Biopharmaceutics and Pharmacokinetics: Overview

2.2K
Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
2.2K
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

109
Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This...
109

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FAQs About Pharmacist Management of Uncomplicated Lower Urinary Tract Infections.

The Annals of pharmacotherapy·2026
Same author

Frequently asked questions (FAQs) on pharmacists' standard of care (SOC) regulation.

Research in social & administrative pharmacy : RSAP·2026
Same author

Pharmacist provider status in Medicaid: A state health director's perspective on policy and practice.

Journal of the American Pharmacists Association : JAPhA·2025
Same author

The MPJE at a Crossroads: Is the Uniform Multistate Pharmacy Jurisprudence Examination Even Necessary?

The Annals of pharmacotherapy·2025
Same author

State Variation in Uptake of Pharmacy-Based CLIA-Waived Testing: Impact of Laws and Regulations.

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians·2024
Same author

Tiered Licensure for Pharmacy Technicians: Is the Advanced Pharmacy Technician (APhT) License the Model for State Regulators?

The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians·2024
Same journal

Healthcare cost savings through hospital pharmacist-collaborative care in heart failure: A microsimulation study.

Journal of the American Pharmacists Association : JAPhA·2026
Same journal

Assessment of comprehensive medication management incorporating a patient-completed medical and medication history form in community practice.

Journal of the American Pharmacists Association : JAPhA·2026
Same journal

Characterizing how community pharmacy teams engage with social drivers of health (SDOH) during routine workflow: A report from the medication safety research network of Indiana (Rx-SafeNet).

Journal of the American Pharmacists Association : JAPhA·2026
Same journal

Geographic disparities in board-certified ambulatory care pharmacists in Appalachia.

Journal of the American Pharmacists Association : JAPhA·2026
Same journal

Development of consensus criteria for problematic medications in active duty service members.

Journal of the American Pharmacists Association : JAPhA·2026
Same journal

Barriers and facilitators to pharmacy-based methadone dosing and dispensing: Semi-structured interviews with pharmacists.

Journal of the American Pharmacists Association : JAPhA·2026
See all related articles

Related Experiment Video

Updated: Aug 7, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
07:32

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

11.4K

Facilitating multistate pharmacy practice: Streamlining continuing pharmacy education requirements.

Alex J Adams

    Journal of the American Pharmacists Association : Japha
    |March 9, 2023
    PubMed
    Summary
    This summary is machine-generated.

    State-specific Continuing Pharmacy Education (CPE) mandates hinder multistate pharmacist licensure. Adopting a nursing compact model for CPE regulation offers a streamlined solution for pharmacists practicing across state lines.

    More Related Videos

    Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
    09:30

    Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

    Published on: March 17, 2023

    3.5K
    Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
    04:36

    Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

    Published on: August 5, 2020

    4.3K

    Related Experiment Videos

    Last Updated: Aug 7, 2025

    Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
    07:32

    Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

    Published on: August 28, 2015

    11.4K
    Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
    09:30

    Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

    Published on: March 17, 2023

    3.5K
    Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
    04:36

    Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

    Published on: August 5, 2020

    4.3K

    Area of Science:

    • Pharmacy regulation
    • Professional licensure
    • Continuing education

    Background:

    • Multistate pharmacist licensure is impeded by diverse state-specific Continuing Pharmacy Education (CPE) requirements.
    • Variations in CPE mandates across six key domains create administrative burdens for pharmacists licensed in multiple states.

    Purpose of the Study:

    • To identify regulatory barriers to multistate pharmacist licensure.
    • To propose a viable regulatory model for Continuing Pharmacy Education (CPE) to facilitate multistate practice.

    Main Methods:

    • Analysis of state-specific Continuing Pharmacy Education (CPE) mandates.
    • Evaluation of the nursing compact model for regulatory application in pharmacy.

    Main Results:

    • State-specific CPE requirements represent a significant regulatory hurdle for multistate pharmacists.
    • The nursing compact model for CPE regulation is identified as a practical short-term solution.

    Conclusions:

    • Replicating the nursing compact model for CPE regulation is the most feasible approach to ease multistate pharmacist licensure.
    • This model allows pharmacists to adhere to the CPE requirements of their primary residence state, with automatic recognition in other practicing states.