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Effects of topically-applied antiperspirant on sweat gland function
S A McWilliams1, I Montgomery, D M Jenkinson
1Institute of Physiology, University of Glasgow, U.K.
The British Journal of Dermatology
|November 1, 1987
Summary
Topical aluminium zirconium tetrachlorhydrate temporarily delays sweating in hot environments by blocking sweat ducts. Ionic transport in sweat glands was also affected, but the overall sweating response was not prevented.
Area of Science:
- Physiology
- Dermatology
- Environmental Health
Background:
- Understanding thermoregulation is crucial for managing heat stress.
- Antiperspirants aim to reduce sweating, but their precise mechanisms require further investigation.
Purpose of the Study:
- To investigate the effect of aluminium zirconium tetrachlorhydrate on sweating onset and intensity.
- To elucidate the underlying mechanisms of antiperspirant action in a hot environment.
Main Methods:
- Subjects were exposed to a hot environment.
- Short-term topical pretreatment with aluminium zirconium tetrachlorhydrate was applied.
- Onset and visible sweating response were monitored; microanalytical evidence was gathered.
Main Results:
- Aluminium zirconium tetrachlorhydrate significantly delayed the onset of visible sweating.
- The antiperspirant did not prevent the sweating response.
- Occlusive action of aluminium conglomerates in the epidermis and modified ionic transport were observed.
Conclusions:
- Topical aluminium zirconium tetrachlorhydrate provides a temporary delay in sweating via duct occlusion.
- The compound also influences ionic transport within sweat gland cells.
- Complete prevention of sweating was not achieved, suggesting limitations in its efficacy under prolonged heat exposure.