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Familial lupus anticoagulants.

I J Mackie1, C B Colaco, S J Machin

  • 1Department of Haematology, Middlesex Hospital Medical School, London.

British Journal of Haematology
|November 1, 1987
PubMed
Summary

Investigating lupus families revealed that prolonged KPTT, indicating lupus anticoagulant (LA), was common even in healthy relatives. Anticardiolipin antibody levels did not consistently correlate with LA severity, suggesting environmental factors in lupus-like disorders.

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Area of Science:

  • Hematology
  • Immunology
  • Genetics

Background:

  • Systemic lupus erythematosus (SLE) and lupus-like diseases can present with coagulation abnormalities.
  • Lupus anticoagulant (LA) is an autoantibody associated with increased thrombotic risk.
  • The familial occurrence of SLE suggests potential genetic or environmental influences.

Purpose of the Study:

  • To investigate coagulation abnormalities in families with multiple members affected by SLE or lupus-like disease.
  • To assess the prevalence of lupus anticoagulant (LA) and anticardiolipin (CL) antibodies within these families.
  • To explore potential environmental or transmissible factors contributing to lupus-like disorders.

Main Methods:

  • Global coagulation tests, including dilute thromboplastin, Russell's viper venom, and thermal stability/absorption assays.
  • Radioimmunoassay (RIA) for anticardiolipin (CL) antibodies.
  • Investigation of three families with multiple affected members.

Main Results:

  • Eleven out of 19 individuals had SLE or lupus-like disease; 8 showed evidence of LA with prolonged KPTT.
  • Five of the 11 affected individuals had high anticardiolipin titres.
  • Prolonged, non-correctable KPTTs were observed in healthy relatives (spouses and siblings) without bleeding or thrombotic history.
  • No close correlation was found between KPTT length and anticardiolipin titre.

Conclusions:

  • Unexplained prolonged KPTT in routine screening may indicate LA, potentially in asymptomatic individuals.
  • The presence of LA and prolonged KPTT in healthy family members suggests non-genetic factors, possibly transmissible agents or environmental influences, may play a role in lupus-like disorders.
  • Anticardiolipin antibody levels may not be a reliable indicator of LA severity or risk.

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