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Quantitative 3D In Silico Modeling q3DISM of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
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MicroRNAs and MAPKs: Evidence of These Molecular Interactions in Alzheimer's Disease

Ivana Raffaele1, Serena Silvestro1, Emanuela Mazzon1

  • 1IRCCS Centro Neurolesi Bonino Pulejo, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.

International Journal of Molecular Sciences
|March 11, 2023
PubMed

Insights

MicroRNAs (miRNAs) are implicated in Alzheimer's disease (AD) by affecting mitogen-activated protein kinases (MAPK) signaling. Targeting specific miRNAs, like miR-132, shows potential for treating AD by reducing pathology and improving cognition.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Alzheimer's disease (AD) is the primary cause of dementia globally, characterized by neurodegeneration.
  • Dysregulated microRNAs (miRNAs) are observed in AD patients, suggesting their involvement in disease progression.
  • Mitogen-activated protein kinases (MAPK) signaling pathways are crucial in cellular functions and can be disrupted in AD.

Purpose of the Study:

  • To review the molecular interplay between miRNAs and MAPKs in Alzheimer's disease pathogenesis.
  • To consolidate evidence from experimental AD models regarding miRNA-MAPK interactions.
  • To identify specific miRNAs with therapeutic potential in AD.

Main Methods:

  • Systematic literature review of publications from 2010-2023.
  • Searches conducted on PubMed and Web of Science databases.
  • Focus on experimental models of Alzheimer's disease.

Main Results:

  • Multiple miRNA deregulations were found to modulate MAPK signaling in various stages of AD.
  • Modulation of MAPK-regulating miRNAs (overexpression or silencing) ameliorated cognitive deficits in AD animal models.
  • miR-132 demonstrated neuroprotective effects by inhibiting amyloid-beta and Tau pathology and oxidative stress via ERK/MAPK1 signaling.

Conclusions:

  • miRNAs play a significant role in regulating MAPK signaling during AD pathogenesis.
  • miRNA-based interventions show promise for improving cognitive function in AD models.
  • Further research is needed to validate and translate these findings into clinical applications for Alzheimer's disease.
Keywords:
Alzheimer’s diseaseMAPKmicroRNAsneurodegeneration

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