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Updated: Aug 7, 2025
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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
Published on: December 23, 2022
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Patent Foramen Ovale and Cryptogenic Stroke: Integrated Management.
Fabiana Lucà1, Paolo G Pino2, Iris Parrini3
1Cardiology Department, Grande Ospedale Metropolitano, GOM, AO Bianchi Melacrino Morelli, 89129 Reggio di Calabria, Italy.
Journal of Clinical Medicine
|March 11, 2023
Summary
Patent foramen ovale (PFO), a common heart defect, is linked to stroke. This review clarifies which patients benefit most from percutaneous PFO device closure (PPFOC) to prevent paradoxical embolism.
Area of Science:
- Cardiology
- Interventional Cardiology
- Vascular Medicine
Background:
- Patent foramen ovale (PFO) affects 25% of the population, increasing risks of cryptogenic stroke and systemic embolization.
- Percutaneous PFO device closure (PPFOC) is supported by evidence, particularly for patients with coexisting interatrial septal aneurysms or large shunts.
Purpose of the Study:
- To review and clarify patient selection criteria for PFO closure.
- To provide updated guidance on optimal candidates for percutaneous PFO device closure.
Main Methods:
- Literature review of clinical trials, meta-analyses, and position papers.
- Analysis of evidence supporting PFO closure strategies.
Main Results:
- Evidence supports PPFOC in specific patient groups, including younger individuals with large shunts and those with septal aneurysms.
- Accurate patient evaluation is crucial for successful PFO closure outcomes.
Conclusions:
- Refined patient selection is essential for optimizing the benefits of PFO closure.
- Further clarification on indications for PPFOC will improve treatment efficacy and patient selection.
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