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Nanoparticle targeting of mechanically modulated glycocalyx
Afia Ibnat Kohon1,2, Kun Man1, Katelyn Mathis1,2
1Department of Biomedical Engineering, University of North Texas, 3940 N Elm St., Denton, TX 76207.
Biorxiv : the Preprint Server for Biology
|March 13, 2023
Summary
Mechanical forces and stiffness in the lung microenvironment significantly alter cancer cell glycocalyx. Targeted nanoparticles show improved uptake based on specific mechanical cues, optimizing nanotherapeutic design for lung cancer.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Nanotechnology
Background:
- The lung's extracellular environment, including mechanical forces and matrix stiffness, influences alveolar epithelial cell behavior.
- Changes in interstitial stiffness are observed in lung diseases like fibrosis and cancer.
- Breathing induces cyclic stretches on alveolar cells, impacting their function.
Conclusions:
- Mechanical stiffness and stretching are critical factors in alveolar cell behavior and lung cancer.
- Nanotherapeutic design must consider these mechanical properties for effective lung cancer treatment.
- Targeted delivery of LNPs can be optimized by matching nanoparticle ligands to specific glycans influenced by mechanical cues.
