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Single breath-hold three-dimensional whole-heart T2 mapping with low-rank plus sparse reconstruction
Dongyue Si1, Xiangchuang Kong2,3, Rui Guo4
1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China.
NMR in Biomedicine
|March 13, 2023
Summary
A new rapid cardiac T2 mapping technique, 3D BOLT, enables whole-heart measurement within a single breath-hold. This method demonstrates accuracy, precision, and repeatability, offering a significant advancement for cardiac imaging.
Area of Science:
- Medical Imaging
- Cardiovascular Magnetic Resonance
- Quantitative MRI
Background:
- Accurate T2 mapping is crucial for assessing myocardial tissue characteristics.
- Existing cardiac T2 mapping techniques often require long scan times or free-breathing, limiting clinical applicability.
- Rapid and robust whole-heart T2 measurement remains a challenge.
Purpose of the Study:
- To develop and evaluate a novel three-dimensional single Breath-hOLd cardiac T2 mapping sequence (3D BOLT) for rapid whole-heart T2 measurement.
- To assess the accuracy, precision, and repeatability of the 3D BOLT sequence.
- To validate 3D BOLT against established cardiac T2 mapping methods.
Main Methods:
- Development of a 3D Breath-hOLd cardiac T2 mapping (3D BOLT) sequence utilizing low-rank plus sparse (L+S) reconstruction.
- Acquisition of three accelerated, electrocardiogram-triggered volumes with whole-heart coverage within a single 12-heartbeat breath-hold.
- Optimization and validation against gradient spin echo (GraSE) and a previously published 3D free-breathing T2 mapping (3DFBT2) sequence in phantoms and human subjects.
Main Results:
- 3D BOLT achieved T2 measurements comparable to fully sampled data with 4.2-fold acceleration.
- Phantom studies demonstrated good accuracy and precision (R² > 0.99) compared to reference values.
- In vivo studies showed comparable and consistent left ventricle T2 values between 3D BOLT, GraSE, and 3DFBT2 in healthy subjects and patients.
- Excellent agreement and repeatability (ICC: 0.938) were observed between 3D BOLT and 3DFBT2 myocardial T2 measurements.
Conclusions:
- The proposed 3D BOLT sequence enables rapid, whole-heart T2 mapping within a single breath-hold.
- 3D BOLT provides accurate, precise, and repeatable T2 measurements, outperforming previous methods in scan time efficiency.
- This technique holds significant potential for improved clinical assessment of myocardial tissue.
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