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Updated: Aug 7, 2025

Use of a Rat Model to Study Ventral Abdominal Hernia Repair
Published on: October 2, 2017
Results of Experimental Hernioplasty with Acellular Dermal Matrix
K I Melkonyan1, K I Popandopulo2, S B Bazlov2
1Ministry of Health of the Russian Federation, Kuban State Medical University, Krasnodar, Russia. cnil.ksma@yandex.ru.
Abstract:
We performed a comprehensive assessment of the acellular dermal matrix obtained during the detergent-enzymatic treatment of the porcine dermis. Acellular dermal matrix was used for the experimental treatment of a hernial defect in a pig using the sublay method. Sixty days after the surgery, biopsy specimens were obtained from the area of hernia repair. The acellular dermal matrix can be easily modeled depending on the size and shape of the defect during surgical procedures, can eliminate the defect of the anterior abdominal wall, and is resistant to cutting by the suture material. Histological examination demonstrated replacement of the acellular dermal matrix with newly formed connective tissue.
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