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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

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A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Related Experiment Video

Updated: Aug 7, 2025

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

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Autoimmune Skin Conditions: Psoriasis.

Karl T Clebak1, Leesha A Helm1, Galen Foulke2

  • 1Department of Family and Community Medicine - Penn State College of Medicine, 700 HMC Crescent Road, Hershey, PA 17033.

FP Essentials
|March 13, 2023
PubMed
Summary
This summary is machine-generated.

Psoriasis is a chronic inflammatory skin disease affecting 3.2% of Americans, influenced by genetics and environment. Management involves lifestyle changes, topical treatments for mild cases, and systemic therapies for severe psoriasis, with attention to associated health conditions.

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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Area of Science:

  • Dermatology
  • Immunology
  • Public Health

Background:

  • Psoriasis is a chronic inflammatory skin condition impacting quality of life.
  • It affects 3.2% of the U.S. population, stemming from genetic and environmental factors.
  • Associated comorbidities include cardiovascular disease, diabetes, and inflammatory bowel diseases.

Purpose of the Study:

  • To provide a comprehensive overview of psoriasis.
  • To discuss various clinical variants of the disease.
  • To highlight treatment strategies and the importance of managing comorbidities.

Main Methods:

  • Review of existing literature on psoriasis.
  • Classification of psoriasis variants.
  • Summary of current therapeutic approaches.

Main Results:

  • Psoriasis presents in several clinical forms: chronic plaque, guttate, pustular, inverse, and erythrodermic.
  • Limited disease is managed with lifestyle modifications and topical agents (emollients, coal tar, corticosteroids, vitamin D analogues, calcineurin inhibitors).
  • Severe psoriasis necessitates systemic treatments, including oral or biologic therapies.

Conclusions:

  • Individualized management plans combining various treatments are crucial for psoriasis.
  • Patient counseling regarding associated comorbidities is essential for holistic care.
  • Effective psoriasis management requires addressing both skin symptoms and systemic health implications.