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Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Updated: Aug 7, 2025

Murine Full-thickness Skin Transplantation

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Split thickness skin graft compression: a scoping review.

Francene Kavanagh¹, Shaani Singhal¹, Warren M Rozen¹

¹Department of Plastic and Reconstructive Surgery, Peninsula Clinical School, Central Clinical School, Faculty of Medicine, Monash University, Frankston, Australia.

|March 14, 2023

Summary

This summary is machine-generated.

Postoperative compression therapy shows limited evidence for improving split thickness skin graft (STSG) success in lower limb reconstructions, especially after cancer surgery. More research is needed to confirm its benefits for patients prone to swelling.

Keywords:

Split thickness skin graft (STSG)compression lymph node negative pressure wound therapy (NPWT)vacuum assisted closure (VAC)

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Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair

Published on: February 24, 2016

Area of Science:

Reconstructive Surgery
Dermatology
Oncology

Background:

Split thickness skin graft (STSG) is a common procedure for lower limb reconstruction after malignancy excision.
Postoperative management, including compression therapy, lacks robust evidence for optimizing STSG outcomes.
Compression may be beneficial for graft take and complication reduction, particularly in patients with lymphedema risk.

Purpose of the Study:

To review the existing literature on the efficacy of postoperative compression therapy for split thickness skin grafts (STSG) on the lower limb.
To assess the evidence for compression therapy in STSG, especially in patients undergoing concurrent lymph node procedures.

Main Methods:

A comprehensive literature search was conducted on PubMed using terms related to STSG, compression, and edema.
Initial searches yielded no direct results, necessitating broader terms like "compression," "pressure," and "split thickness skin graft."
A total of 383 articles were identified, with 100 selected for abstract review.

Main Results:

Only 12% (12/100) of reviewed articles focused on compression therapy for STSG, with none specifically addressing oncological resection cases.
Negative pressure wound therapy (NPWT) was frequently cited (80%) as an established adjunct for promoting STSG take.
Evidence supporting compression therapy for lower limb STSG, particularly post-lymph node procedures, is scarce.

Conclusions:

The demonstrated efficacy of postoperative compression therapy for lower limb STSG is limited.
Further large-scale, prospective trials are warranted to validate compression therapy as a beneficial adjunct for STSG in susceptible patient populations.
Compression therapy is a potentially simple, cost-effective method that requires further investigation for STSG.