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Updated: Aug 6, 2025
09:20
CRISPR-Mediated Reorganization of Chromatin Loop Structure
Published on: September 14, 2018
12.6K
Regulation of loop extrusion on the interphase genome
Hyogyung Shin1, Yoori Kim1,2
1Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Korea.
Critical Reviews in Biochemistry and Molecular Biology
|March 15, 2023
Summary
Cohesin-mediated loop extrusion shapes genome architecture. Regulators control cohesin loading, impacting chromatin structure, human disorders, and aging.
Area of Science:
- Molecular Biology
- Genetics
- Cell Biology
Background:
- Dynamic chromatin organization is crucial for nuclear processes like gene regulation, DNA replication, and repair.
- Cohesin-mediated loop extrusion is a key mechanism for DNA loop formation.
- Cohesin complex loading and unloading are regulated by interacting factors affecting motor activity.
Conclusions:
- Regulation of cohesin loading is critical for maintaining genome architecture.
- Dysregulation of cohesin dynamics is implicated in human disorders and aging.
- Understanding these mechanisms provides insights into genome organization and associated diseases.
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