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Standardized growth charts for children with osteogenesis imperfecta
Marie-Eve Robinson1,2, Damian Rauch3, Francis H Glorieux3
1Shriners Hospital for Children - Canada, McGill University, Montreal, QC, Canada. mrobinson@cheo.on.ca.
Pediatric Research
|March 16, 2023
Summary
New growth charts for Osteogenesis Imperfecta (OI) provide type- and sex-specific height data for children. These charts help track growth from infancy to adulthood, addressing a critical gap in OI care.
Area of Science:
- Pediatric endocrinology
- Skeletal dysplasias
- Medical genetics
Background:
- Osteogenesis Imperfecta (OI) is characterized by short stature, varying by type (mild, moderate, severe).
- Existing pediatric growth charts lack specificity for OI types and sex.
- There is a need for standardized growth assessment tools for individuals with OI.
Purpose of the Study:
- To develop standardized, type- and sex-specific growth charts for Osteogenesis Imperfecta (OI) across all pediatric ages.
- To provide clinicians with tools for monitoring growth in children with OI.
- To generate height multiplier curves for predicting adult height in OI patients.
Main Methods:
- Collected height data from 573 individuals with OI (types I, III, IV) aged 3 months to 20 years (6523 observations).
- Generated OI type- and sex-specific growth charts for infants and children/adolescents using the LMS method.
- Smoothed percentile curves for accurate growth assessment.
Main Results:
- Age-related decline in height z-scores was observed across all OI types, more pronounced in females.
- Developed type- and sex-specific growth charts for OI from infancy through adolescence.
- Created height multiplier curves to predict adult height for children with OI.
Conclusions:
- The newly developed standardized growth charts enable comprehensive growth assessment for individuals with OI from infancy to adulthood.
- These charts address a significant unmet need in the clinical management of Osteogenesis Imperfecta.
- The study provides the first set of OI-specific growth charts for pediatric populations.
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