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Updated: Aug 6, 2025

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
Published on: July 22, 2021
Osteoarthritis year in review 2022: imaging
S Demehri1, A Kasaeian1, F W Roemer2
1Musculoskeletal Radiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Recent osteoarthritis imaging research highlights artificial intelligence (AI) integration. Magnetic resonance imaging (MRI) remains prevalent, while AI shows promise in predicting disease progression and analyzing joint structures.
Area of Science:
- Orthopedics and Imaging Science
- Biomedical Engineering and Artificial Intelligence
Background:
- Osteoarthritis (OA) research increasingly utilizes advanced imaging techniques.
- Large open-access databases are a growing resource in OA studies.
Purpose of the Study:
- To review original research on osteoarthritis imaging published between April 2021 and March 2022.
- To focus on in vivo human studies of OA imaging modalities and artificial intelligence applications.
Main Methods:
- Systematic literature search of PubMed, Medline, Embase, Scopus, and ISI Web of Science.
- Keywords included "Osteoarthritis/OA", "Radiography", "Ultrasound/US", "Computed Tomography/CT", "DXA", "Magnetic Resonance Imaging/MRI", "Artificial Intelligence/AI", and "Deep Learning".
- Analysis of research focus on tibiofemoral, patellofemoral, hip, and hand joints.
Main Results:
- Compositional MRI is a prominent imaging modality for OA, with biomarkers aiding preclinical detection and outcome prediction.
- A significant increase in publications on artificial intelligence applications in OA imaging, including prediction models and trabecular texture analysis.
- The use of open-access large databases has plateaued.
Conclusions:
- Imaging remains crucial in osteoarthritis research, with a growing emphasis on integrating artificial intelligence (AI).
- Magnetic resonance imaging (MRI) shows the highest prevalence, while ultrasound (US) and computed tomography (CT) are readily available.
- AI techniques for texture analysis and OA progression prediction are seeing increased development and validation.
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