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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

572
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

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Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
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The abscopal effect: Implications for drug discovery in autoimmunity.

Sylviane Muller1

  • 1CNRS and Strasbourg University Unit Biotechnology and Cell signalling/Strasbourg Drug Discovery and Development Institute (IMS), Strasbourg, France; Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg University, Strasbourg, France; University of Strasbourg Institute for Advanced Study (USIAS), Strasbourg, France.

Autoimmunity Reviews
|March 16, 2023
PubMed
Summary

Novel targeted therapies improve autoimmune disease (AD) outcomes but face resistance and side effects. Exploring treatments with abscopal effects may offer a promising future for immune tolerance in ADs.

Keywords:
Autoimmune diseasesAutophagyBystander effectLysosomesPeptide P140Therapeutic strategy

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Area of Science:

  • Immunology
  • Pharmacology
  • Autoimmune Diseases

Background:

  • Targeted therapies have advanced autoimmune disease (AD) treatment by modulating T- and B-cells and inflammatory mediators.
  • Current strategies face limitations including drug resistance, side effects, and challenges in treating non-organ-specific ADs due to unknown antigens.

Purpose of the Study:

  • To explore the potential of novel therapeutic strategies for autoimmune diseases.
  • To investigate the efficacy of treatments with abscopal effects in managing autoimmune conditions.

Main Methods:

  • Review of recent advancements in targeted therapies for autoimmune diseases.
  • Analysis of limitations of current treatment modalities.
  • Exploration of the potential application of abscopal effects in AD treatment.

Main Results:

  • Targeted therapies have improved treatment outcomes but exhibit limitations like drug resistance and side effects.
  • Abscopal effects, observed in cancer therapy, present a potential avenue for treating widespread autoimmune activity.

Conclusions:

  • Future research should focus on developing small molecule- and peptide-based treatments with abscopal effects.
  • These novel treatments aim to induce immune tolerance and clinical quiescence, improving patients' quality of life.