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Updated: Aug 6, 2025
05:26
Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
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[Cardiogenic shock due to phosphine poisoning]
Jan W Buikema1,2, Maarten J Cramer1, Lienke de Vries Feyens3
1Universitair Medisch Centrum Utrecht, afd. Cardiologie, Utrecht.
Nederlands Tijdschrift Voor Geneeskunde
|March 17, 2023
Summary
Toxic inhalations from phosphide gas are rare but serious, mimicking viral infections. Prompt diagnosis is crucial for managing acute heart and multi-organ failure, often linked to mitochondrial dysfunction.
Area of Science:
- Toxicology
- Environmental Health
Background:
- Toxic inhalations are a rare cause of poisoning in the Netherlands.
- Initial symptoms can mimic acute viral infections.
- Aluminum or zinc phosphide is used in the maritime sector for rodent control.
Observation:
- Two patients presented with intoxication from gaseous phosphide used as a grain fumigant.
- Exposure caused respiratory and gastrointestinal symptoms.
- One patient developed respiratory insufficiency, multi-organ failure, and cardiogenic shock.
Findings:
- Phosphide gas poisoning can lead to transient acute heart and multi-organ failure.
- Mitochondrial dysfunction is a primary mechanism of toxicity.
- Unexplained incapacitation warrants consideration of toxic inhalations.
Implications:
- Highlights the importance of considering toxic inhalations in differential diagnoses.
- Emphasizes the potential for severe, multi-systemic effects from phosphide gas exposure.
- Underscores the need for awareness in occupational and environmental health settings.
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