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Comparing endometrial preparation methods in frozen embryo transfers - Does a previous live birth make a difference?
Nikki Lee1, Mahua Bhaduri1, Tarek El-Toukhy1
1Assisted Conception Unit, 11th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, United Kingdom.
Summary
A prior live birth does not impact frozen embryo transfer (FET) success rates. Both medicated and natural endometrial preparation methods yield similar outcomes, irrespective of a patient's fertility history.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization (IVF)
Background:
- Endometrial preparation is crucial for frozen embryo transfer (FET) success.
- The influence of prior fertility outcomes on FET success with different preparation methods is not fully understood.
Purpose of the Study:
- To compare the live birth rate (LBR) of medicated versus natural endometrial preparation for FET.
- To determine if a history of failed fresh cycles affects FET outcomes in subsequent frozen cycles.
Main Methods:
- Retrospective matched case-controlled study.
- Analysis of 878 frozen embryo transfer cycles over two years.
- Adjustment for key variables including embryos transferred, endometrial thickness, and prior embryo transfers.
Main Results:
- No statistically significant difference in live birth rate (LBR) was observed between medicated-FET and natural-FET groups (p=0.08).
- This finding held true regardless of the patient's previous fertility outcome.
Conclusions:
- Previous live birth history does not influence the success of frozen embryo transfer cycles.
- Both medicated and natural endometrial preparation protocols are equally effective for FET, irrespective of prior fertility history.
