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Mycophenolate mofetil-induced hyperlipidemia with cutaneous manifestations
Rebecca M Yim1, Vikram N Sahni2, Jason G Mathis2
1Tulane University School of Medicine New Orleans Louisiana USA.
Clinical Case Reports
|March 20, 2023
Summary
A woman developed xanthomas, skin growths, after starting Mycophenolate mofetil for systemic lupus erythematosus (SLE). Stopping the medication led to remission of both the xanthomas and SLE.
Area of Science:
- Dermatology
- Rheumatology
- Pharmacology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Mycophenolate mofetil is an immunosuppressive drug used to manage SLE.
- Cutaneous manifestations are common in SLE, but drug-induced dermatoses require careful evaluation.
Observation:
- A 49-year-old woman with SLE developed biopsy-proven xanthomas on her hands and arms.
- These xanthomas appeared after the initiation of Mycophenolate mofetil therapy.
- The patient's SLE was being treated with Mycophenolate mofetil.
Findings:
- Cessation of Mycophenolate mofetil therapy resulted in the remission of the xanthomas.
- The patient also achieved remission of her systemic lupus erythematosus.
- This suggests a potential causal link between Mycophenolate mofetil and xanthoma development in this patient.
Implications:
- Mycophenolate mofetil may be associated with xanthoma formation in some SLE patients.
- Discontinuation of the drug can lead to resolution of these cutaneous lesions.
- Further investigation is warranted to understand the mechanism and incidence of this adverse drug reaction.
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