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Related Experiment Video

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Upper Airway Stimulation Therapy Effect on Blood Pressure.

Alex J McKinlay1,2, Benjamin K Walters1, James K Aden3

  • 1Department of Otolaryngology, Brooke Army Medical Center, San Antonio, Texas, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|March 20, 2023
PubMed
Summary

Upper airway stimulation (UAS) therapy significantly reduced blood pressure in patients with obstructive sleep apnea. This treatment also lowered the apnea-hypopnea index, potentially decreasing cardiovascular risks.

Keywords:
apnea-hypopnea indexblood pressurehypertensionobstructive sleep apneaupper airway stimulation

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Area of Science:

  • Cardiology
  • Sleep Medicine
  • Medical Devices

Background:

  • Obstructive sleep apnea (OSA) is a prevalent condition linked to hypertension.
  • Hypertension is a significant risk factor for cardiovascular morbidity.
  • Upper airway stimulation (UAS) therapy is an emerging treatment for OSA.

Purpose of the Study:

  • To evaluate the impact of UAS therapy on blood pressure (BP) in patients with OSA.
  • To assess changes in the apnea-hypopnea index (AHI) following UAS implantation.
  • To determine the potential cardiovascular benefits of UAS therapy.

Main Methods:

  • Retrospective cross-sectional cohort study.
  • Included patients who underwent UAS implantation and used the device for at least 25 hours/week.
  • Compared pre- and postoperative systolic BP, diastolic blood pressure (DBP), mean arterial pressure (MAP), and AHI using paired t-tests or Wilcoxon's signed-rank tests.

Main Results:

  • Thirty patients met the inclusion criteria (median age 60, median BMI 29.9 kg/m²).
  • AHI decreased significantly from 35.1 to 16.5 events/h (p < .001).
  • DBP decreased by a mean of 3.7 mm Hg (p = .002) and MAP by 3.7 mm Hg (p = .004).

Conclusions:

  • UAS therapy is associated with significant reductions in DBP, MAP, and AHI.
  • These BP reductions may contribute to decreased cardiovascular morbidity.
  • UAS therapy presents a viable treatment option for OSA patients with hypertension.