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Published on: August 18, 2017
Synthesis and Chiroptical Properties of a Chiral Isotopologue of syn-Cryptophane-B
Thierry Brotin1, Nicolas Daugey2, Josef Kapitan3
1ENSL, UMR 5182-CNRS, Laboratoire de Chimie, 46 Allée d'Italie, 69364 Lyon, France.
Abstract:
We report the synthesis and absolute configuration (AC) of a chiral isotopologue of syn-cryptophane-B. Low chiral signatures were measured by polarimetry and electronic circular dichroism, whereas most significant chiroptical effects were observed by vibrational circular dichroism (VCD) and Raman optical activity (ROA). The comparison of experimental VCD and ROA spectra with those predicted by DFT calculations allows the determination of the AC of the two enantiomers as (-)589-MP-syn-2 and (+)589-PM-syn-2.
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