Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

110
Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
110

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

One-Step Assembly of Versatile Multifunctional Coatings Based on Host-Guest and Polyphenol Chemistry.

Small (Weinheim an der Bergstrasse, Germany)·2023
Same author

Tyrosine-Based Dual-Functional Interface for Trapping and On-Site Photo-Induced Covalent Immobilization of Proteins.

Bioconjugate chemistry·2022
Same author

Modular Chamber Assembled with Cell-Replicated Surface for Capture of Cancer Cells.

ACS biomaterials science & engineering·2021
Same author

Natural Fish Trap-Like Nanocage for Label-Free Capture of Circulating Tumor Cells.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2020
Same author

A monitoring-modeling approach to SO<sub>4</sub><sup>2-</sup> and NO<sub>3</sub><sup>-</sup> secondary conversion ratio estimation during haze periods in Beijing, China.

Journal of environmental sciences (China)·2019
Same author

Short Versus Long Cephalomedullary Nails for Fixation of Stable Versus Unstable Intertrochanteric Femur Fractures at a Level 1 Trauma Center.

Orthopedics·2019

Related Experiment Video

Updated: Aug 6, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
05:45

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

3.5K

Bacteria-Induced Colloidal Encapsulation for Probiotic Oral Delivery.

Chong Zhang1, Xiaorong Gao1, Xinxiu Ren1

  • 1Liaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian 116023, People's Republic of China.

ACS Nano
|March 22, 2023
PubMed
Summary

A novel bacteria-induced encapsulation strategy enhances probiotic oral delivery by protecting them in the harsh gastrointestinal tract. This method significantly improves probiotic survival, colonization, and therapeutic efficacy for various diseases.

Keywords:
bacteria-induced encapsulationcolloidal assemblygut microbiotahost−guest interactionsprobiotic oral delivery

More Related Videos

Bacterial Cellulose Spheres that Encapsulate Solid Materials
04:42

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

4.5K
Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
12:12

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

12.5K

Related Experiment Videos

Last Updated: Aug 6, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
05:45

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

3.5K
Bacterial Cellulose Spheres that Encapsulate Solid Materials
04:42

Bacterial Cellulose Spheres that Encapsulate Solid Materials

Published on: February 26, 2021

4.5K
Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice
12:12

Transformation of Probiotic Yeast and Their Recovery from Gastrointestinal Immune Tissues Following Oral Gavage in Mice

Published on: February 8, 2016

12.5K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Microbiology

Background:

  • Oral delivery of probiotics is critical for biomedical applications.
  • Limited probiotic survival and colonization in the gastrointestinal tract hinder oral bioavailability.
  • Developing effective strategies to protect probiotics during oral delivery is essential.

Purpose of the Study:

  • To develop a bacteria-induced encapsulation strategy to enhance probiotic oral bioavailability.
  • To investigate the protective effects of the encapsulation on probiotic survival and function.
  • To evaluate the therapeutic efficacy of encapsulated probiotics in a colitis model.

Main Methods:

  • Utilizing a bacteria-induced encapsulation strategy with metastable colloids (NTc) composed of amino-modified poly-β-cyclodextrin and tannic acid.
  • Assembling NTc colloids around negatively charged probiotics through electrostatic attraction and host-guest interactions.
  • Assessing probiotic survival in simulated gastric fluid and evaluating proliferation, adhesion, and therapeutic efficacy in vitro and in vivo.

Main Results:

  • Achieved rapid encapsulation of 97% of bacteria within 10 s using a one-step mixing process.
  • Demonstrated significantly enhanced probiotic survival (19%) in simulated gastric fluid, 7500 times greater than commercial materials.
  • Confirmed sustained probiotic proliferation, durable intestinal adhesion, and improved therapeutic efficacy in a colitis mouse model.

Conclusions:

  • The bacteria-induced colloidal encapsulation strategy effectively enhances probiotic oral bioavailability and therapeutic outcomes.
  • The developed NTc shells provide robust protection against the gastrointestinal environment while supporting probiotic activity.
  • This facile encapsulation approach holds potential for oral delivery of various microbes as therapeutic bioagents.