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Male Reproduction and Aging.

Maria Gabriela Figueiredo1, Thiago Gagliano-Jucá2, Shehzad Basaria3

  • 1Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 541, Boston, MA 02115, USA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Endocrinology and Metabolism Clinics of North America
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Summary
This summary is machine-generated.

Late-onset hypogonadism is uncommon. Testosterone therapy offers modest benefits for some older men, but risks for prostate cancer and cardiovascular events require further study.

Keywords:
Androgen deficiencyLate-onset hypogonadismTestosterone replacement therapy

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Area of Science:

  • Endocrinology
  • Men's Health
  • Geriatrics

Background:

  • Recent studies indicate a low prevalence of symptomatic late-onset hypogonadism (age-related low testosterone).
  • Testosterone therapy in middle-aged and older men shows modest efficacy for specific symptoms like sexual dysfunction, mood, bone density, and anemia.

Purpose of the Study:

  • To evaluate the benefits and risks of testosterone therapy in older men with age-related testosterone decline.
  • To clarify the impact of testosterone therapy on prostate cancer risk and major adverse cardiovascular events.

Main Methods:

  • Review of recent population studies and clinical trials on testosterone therapy.
  • Analysis of efficacy in improving sexual function, mood, bone density, and anemia.
  • Assessment of uncertainties regarding prostate cancer and cardiovascular risks.

Main Results:

  • Syndromic prevalence of age-related low testosterone is low.
  • Testosterone therapy provides modest improvements in sexual function, mood, bone density, and anemia in select older men.
  • The effects on prostate cancer risk and major adverse cardiovascular events are not yet clear.

Conclusions:

  • Testosterone therapy may benefit select older men with age-related testosterone decline.
  • Further research, including the ongoing TRAVERSE trial, is needed to determine the risks associated with testosterone therapy, particularly concerning prostate cancer and cardiovascular events.