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Perspectives on Prediabetes and Aging.

Mohammed E Al-Sofiani1, Alanood Asiri2, Sarah Alajmi2

  • 1Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Central Region, 12372, Saudi Arabia; Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA.

Endocrinology and Metabolism Clinics of North America
|March 22, 2023
PubMed
Summary
This summary is machine-generated.

Diabetes prevention programs can delay diabetes, but prediabetes diagnoses carry risks. This review examines aging

Keywords:
AgingImpaired fasting glucoseImpaired glucose toleranceOlder adultsPrediabetes

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Area of Science:

  • Gerontology
  • Metabolic Health
  • Endocrinology

Background:

  • Diabetes prevention programs (DPPs) effectively delay diabetes progression.
  • Prediabetes diagnosis can lead to negative psychological and financial consequences.
  • Many older adults have low-risk prediabetes that may spontaneously resolve.

Purpose of the Study:

  • To review the impact of aging on glucose metabolism.
  • To propose a holistic approach for managing prediabetes in older adults.
  • To optimize the benefit-risk balance of prediabetes interventions in the elderly.

Main Methods:

  • Literature review on aging and glucose metabolism.
  • Analysis of prediabetes progression in older populations.
  • Development of a risk-benefit framework for interventions.

Main Results:

  • Aging alters glucose metabolism, influencing prediabetes risk and progression.
  • Low-risk prediabetes in older adults often shows limited progression.
  • Interventions must consider the unique physiological changes associated with aging.

Conclusions:

  • A nuanced approach to prediabetes in older adults is necessary.
  • Interventions should be tailored to minimize risks and maximize benefits.
  • Focusing on holistic health rather than solely on prediabetes diagnosis is crucial for this demographic.