Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

1.8K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.8K
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

2.4K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
2.4K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

244
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
244
The Thyroid Gland01:23

The Thyroid Gland

4.1K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.1K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

12
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
12
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

3.9K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Angiogenic Factors in Adult Diffuse Glioma and Their Correlation With Tumor Grade: An Observational Study.

Cureus·2026
Same author

High Immunohistochemical Expression of Runt-Related Transcription Factor 2 (RUNX2) Is Associated With High Tumor Grade, Muscle Invasion, Lymph Node Metastasis, and Advanced Stage in Urinary Bladder Cancer.

Cureus·2026
Same author

Fine Needle Aspiration Cytology in Unveiling a Rare Diagnosis of Lacrimal Sac Solitary Fibrous Tumour and Its Cytological Attributes.

Cureus·2026
Same author

Fluorescent Microscopy: A Useful and Adjunct Tool in Leprosy Diagnosis: A Cross Sectional Study.

Iranian journal of pathology·2025
Same author

Tumor Educated Platelets as a Biomarker for Diagnosis of Lung cancer: A Systematic Review.

Asian Pacific journal of cancer prevention : APJCP·2024
Same author

The spectrum of microvascular patterns in adult diffuse glioma and their correlation with tumor grade.

Journal of pathology and translational medicine·2024

Related Experiment Video

Updated: Aug 6, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

14.7K

Lymphocytic Hypophysitis: An Underrated Disease.

Amruta Ashok Patil1, Purwa Patil2, Vaishali Walke3

  • 1Department of Pathology, Bharati Vidyapeeth Deemed University Medical College, Sangli, India.

Journal of Mid-Life Health
|March 23, 2023
PubMed
Summary

Lymphocytic hypophysitis (LYH) is a rare inflammatory pituitary disease. Intraoperative diagnosis is crucial to prevent unnecessary surgical removal of the pituitary gland.

Keywords:
Lymphocytic hypophysitispituitary adenomasquash

More Related Videos

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.5K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K

Related Experiment Videos

Last Updated: Aug 6, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
10:52

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

14.7K
Induction of Experimental Autoimmune Hypophysitis in SJL Mice
10:38

Induction of Experimental Autoimmune Hypophysitis in SJL Mice

Published on: December 17, 2010

11.5K
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K

Area of Science:

  • Endocrinology
  • Pathology
  • Oncology

Background:

  • Lymphocytic hypophysitis (LYH) is a rare inflammatory condition affecting the pituitary gland.
  • It can lead to panhypopituitarism, a deficiency of all pituitary hormones.
  • First described in 1962, LYH is often associated with autoimmune processes.

Observation:

  • A case report of a 36-year-old nonpregnant female initially presumed to have a nonsecreting pituitary adenoma.
  • Intraoperative squash cytology and excision biopsy confirmed the diagnosis of LYH.
  • Most reported LYH cases occur in pregnant or postpartum women.

Findings:

  • LYH can mimic nonsecretory pituitary adenomas both clinically and radiologically.
  • Autoimmune associations include lymphocytic infiltration of other endocrine glands and presence of antipituitary antibodies.
  • Accurate diagnosis is often delayed until biopsy or autopsy in literature reviews.

Implications:

  • Intraoperative diagnosis of LYH is vital.
  • It can prevent unnecessary surgical excision of the pituitary gland, preserving function.
  • Highlights the importance of considering autoimmune etiologies in pituitary lesions.