Absolute Grüneisen parameter measurement in deep tissue based on X-ray-induced acoustic computed tomography

Area of Science:

• Biomedical Engineering
• Medical Imaging
• Acoustic Physics

Background:

• The Grüneisen parameter is crucial for understanding the photoacoustic effect and provides biological and temperature change information.
• Accurate measurement of the Grüneisen parameter is vital for advancing biomedical research and diagnostics.

Purpose of the Study:

• To develop and validate a novel method for determining the absolute Grüneisen parameter.
• To simultaneously assess internal body temperature distribution using advanced imaging techniques.

Main Methods:

• Integration of X-ray-induced acoustic tomography with conventional X-ray computed tomography.
• Theoretical development and numerical simulations to support the proposed methodology.
• Exploration of biomedical application scenarios for the technique.

Main Results:

• Successful determination of the absolute Grüneisen parameter.
• Capability to obtain non-invasive internal body temperature distribution maps.
• Demonstration of the method's potential in disease diagnosis.

Conclusions:

• The combined X-ray tomography approach offers a powerful tool for Grüneisen parameter measurement.
• This technique holds significant promise for enhanced medical diagnostics and disease monitoring.
• The ability to map temperature distribution opens new avenues in understanding physiological processes.