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Updated: Aug 5, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Immune checkpoint inhibitor-related thyroid dysfunction.

Frédéric Illouz1, Claire Briet2, Patrice Rodien2

  • 1Service d'endocrinologie, diabétologie et nutrition, CHU d'Angers, centre de référence des maladies rares de la thyroïde et des récepteurs hormonaux (TRH), centre de référence des maladies rares de l'hypophyse (HYPO), 49933 Angers cedex 09, France.

Annales D'Endocrinologie
|March 24, 2023
PubMed
Summary
This summary is machine-generated.

Immune checkpoint inhibitors (ICIs) are crucial cancer treatments. This review covers the frequent thyroid dysfunction side effect, including its epidemiology, diagnosis, management, and risk factors.

Keywords:
Dysfonction thyroïdienneHypothyroidismHypothyroïdieImmune checkpoint inhibitorsInhibiteurs des points de contrôle immunitaireThyroid dysfunctionThyroiditisThyrotoxicoseThyrotoxicosisThyroïdite

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Area of Science:

  • Oncology
  • Immunology
  • Endocrinology

Background:

  • Immune checkpoint inhibitors (ICIs) represent a significant advancement in cancer therapy.
  • Thyroid dysfunction is the most common immune-related adverse event (irAE) associated with ICI treatment.

Approach:

  • This review synthesizes current data on ICI-induced thyroid dysfunction.
  • It examines epidemiological trends, diagnostic criteria, and therapeutic strategies.
  • Risk factors contributing to thyroid dysfunction are also discussed.

Key Points:

  • Thyroid dysfunction is a frequent irAE in patients receiving ICIs.
  • Early diagnosis and appropriate management are essential for patient outcomes.
  • Understanding risk factors can aid in proactive patient monitoring.

Conclusions:

  • ICI therapy necessitates vigilant monitoring for thyroid dysfunction.
  • Further research into predictive markers and optimized management protocols is warranted.