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Monitoring Muscle Perfusion in Rodents During Short-Term Ischemia Using Power Doppler Ultrasound.

Somaye Babaei¹, Bingze Dai², Craig K Abbey³

¹Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Ultrasound in Medicine & Biology

|March 26, 2023

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This summary is machine-generated.

Non-contrast power Doppler ultrasound (PD-US) reliably tracks muscle blood flow changes. This imaging technique can monitor peripheral artery disease progression and treatment effectiveness.

Area of Science:

Biomedical Engineering
Medical Imaging
Physiology

Background:

Peripheral blood perfusion monitoring is crucial for assessing conditions like peripheral artery disease.
Current methods for assessing perfusion may have limitations or require contrast agents.
Power Doppler ultrasound (PD-US) offers a potential non-invasive alternative for evaluating blood flow.

Purpose of the Study:

To evaluate the reliability of non-contrast power Doppler ultrasound (PD-US) for monitoring temporal changes in peripheral muscle blood perfusion.
To validate PD-US measurements against established techniques like laser speckle contrast imaging (LSCI).

Main Methods:

Pre-clinical rodent studies were conducted using both invasive and non-invasive approaches.
PD-US signals were processed using spatial registration and clutter filtering techniques.

Keywords:

Clutter filtering Flow-mediated dilation Hindlimb ischemia Perfusion imaging Peripheral artery disease Rigid registration

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Measurements were compared with LSCI during arterial clamping and with flow-mediated dilation and reactive hyperemia assessments during induced ischemia.

Main Results:

PD-US, combined with signal processing, reproducibly tracked blood perfusion in skeletal muscle.
No significant differences in flow-mediated dilation or reactive hyperemia were observed between sexes or fitness levels.
Exercise conditioning showed a potential enhancement in post-ischemic perfusion.

Conclusions:

Non-contrast PD-US imaging reliably monitors relative spatiotemporal changes in muscle perfusion.
This study supports the development of PD-US for monitoring perfusion in patients at risk for peripheral artery disease.