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Updated: Aug 5, 2025
Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
Published on: July 29, 2013
Development of a multi-purpose quality control phantom for MRI-based treatment planning in high-dose-rate
Abolfazl Kanani1, Amir Owrangi2, Mehran Yazdi3
1Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Purpose:
Suitable commissioning and quality control (QC) tests for high-dose-rate brachytherapy (HDR-BT) is necessary to ensure dosimetric and geometric accuracy of the treatment. This study aimed to present the methodology of developing a novel multi-purpose QC phantom (AQuA-BT) and examples of its' application in 3D image-based (particularly magnetic resonance imaging [MRI]-based) planning for cervix BT.
Material And Methods:
Design criteria led to a phantom with sufficient size waterproof box for dosimetry and capability for inserting other components inside the phantom for: (A) Validating dose calculation algorithms in treatment planning systems (TPSs) using a small-volume ionization chamber; (B) Testing volume calculation accuracy in TPSs for bladder, rectum, and sigmoid organs at risk (OARs) constructed by 3D printing; (C) Quantification of MRI distortions using 17 semi-elliptical plates with 4,317 control points to mimic a realistic female's pelvis size; and (D) Quantification of image distortions and artifacts induced by MRI-compatible applicators using a specific radial fiducial marker. The utility of the phantom was tested in various QC procedures.
Results:
The phantom was successfully implemented for examples of intended QC procedures. The maximum deviation between the absorbed doses to water assessed with our phantom and those calculated by SagiPlan TPS was 1.7%. The mean discrepancy in volumes of TPS-calculated OARs was 1.1%. The differences between known distances within the phantom on MR imaging were within 0.7 mm compared with computed tomography.
Conclusions:
This phantom is a promising useful tool for dosimetric and geometric quality assurance (QA) in MRI-based cervix BT.
