Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

616
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
616
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

882
Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ...
882
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

211
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
211
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.3K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.3K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

21
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
21
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

27
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
27

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of C-Reactive Protein-Triglyceride Glucose Index and TyG Index With Prehypertension and Hypertension.

Immunity, inflammation and disease·2026
Same author

Hypoxia-driven T cell-macrophage-stromal cross-talk sustains fibrosis in preclinical models of cutaneous chronic graft-versus-host disease.

Science translational medicine·2026
Same author

Integrated Transcriptomic and Metabolomic Profiling Reveals Developmental Reprogramming of Flavonoid Biosynthesis in Styphnolobium japonicum Flowers.

Physiologia plantarum·2026
Same author

Comparative evaluation of different MALDI-TOF-MS platforms for plasma IgG N-glycan profiling: impact on analytical performance and clinical conclusions.

Analytical and bioanalytical chemistry·2026
Same author

Modular nucleic acid-based construct for delivery of immunostimulatory agonists and oncogene-silencing oligonucleotides in tumours.

Nature biomedical engineering·2026
Same author

Development of Channelized K/V Band Dicke Microwave Radiometer Based on SDR.

Sensors (Basel, Switzerland)·2026

Related Experiment Video

Updated: Aug 5, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K

High-density lipoprotein cholesterol and carcinogenesis.

Meijuan Tan1, Shijie Yang2, Xiequn Xu1

  • 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Trends in Endocrinology and Metabolism: TEM
|March 27, 2023
PubMed
Summary

High-density lipoprotein cholesterol (HDLC) shows a significant association with cancer incidence and prognosis. Further research into molecular mechanisms could improve cancer prediction and treatment strategies.

Keywords:
cancercarcinogenesisclass B type 1 scavenger receptorhigh-density lipoprotein cholesterolrecombinant high-density lipoprotein

More Related Videos

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

3.6K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K

Related Experiment Videos

Last Updated: Aug 5, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

9.4K
Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
09:27

Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

Published on: April 1, 2021

3.6K
Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.7K

Area of Science:

  • Biochemistry
  • Oncology
  • Cardiovascular Medicine

Background:

  • High-density lipoprotein cholesterol (HDLC) is a known factor in atherosclerosis.
  • Emerging research links HDLC levels to cancer development and progression.
  • A majority of studies indicate an inverse relationship between HDLC and tumor incidence.

Purpose of the Study:

  • To review the impact of HDLC on cancer incidence and prognosis across various cancer types.
  • To explore the potential of serum HDLC as a biomarker for cancer prognosis and tumor assessment.
  • To highlight the need for molecular mechanism studies connecting HDLC and cancer.

Main Methods:

  • Literature review of studies investigating HDLC and cancer.
  • Analysis of associations between HDLC levels and cancer incidence.
  • Examination of HDLC's role in cancer patient prognosis.

Main Results:

  • Evidence suggests a negative correlation between HDLC levels and cancer incidence.
  • Serum HDLC concentrations may serve as a prognostic indicator for cancer patients.
  • The molecular pathways linking HDLC to tumorigenesis require further elucidation.

Conclusions:

  • HDLC influences cancer incidence and patient outcomes.
  • Serum HDLC holds potential as a cancer biomarker.
  • Future research should focus on the molecular mechanisms underlying the HDLC-cancer relationship for improved diagnostics and therapeutics.