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Published on: February 29, 2020
Mesothelial Inclusion Cyst in an Infant with Beckwith-Weidemann Syndrome
Alison J Lehane1, Jessica Rauh1, Leah M Sieren1
1Department of Surgery, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, NC, USA.
Insights
Mesothelial inclusion cysts are rare benign tumors typically found in adults. This report details a rare case of these cysts in an infant with Beckwith-Wiedeman syndrome.
Area of Science:
- Pediatric Pathology
- Developmental Biology
- Oncology
Background:
- Mesothelial inclusion cysts are uncommon benign neoplasms, rarely documented in pediatric cases.
- Existing literature predominantly reports these cysts in adult populations.
- A single prior report suggested a link between mesothelial inclusion cysts and Beckwith-Wiedeman syndrome.
Observation:
- The study presents a unique case of an infant diagnosed with Beckwith-Wiedeman syndrome.
- The infant underwent surgical repair for omphalocele.
- During the procedure, hepatic cysts were identified.
Findings:
- Pathological examination of the hepatic cysts confirmed them to be mesothelial inclusion cysts.
- This finding represents a rare occurrence of mesothelial inclusion cysts in an infant.
- The case highlights a potential association with Beckwith-Wiedeman syndrome in pediatric patients.
Implications:
- This case expands the known clinical spectrum of mesothelial inclusion cysts.
- It underscores the importance of considering this diagnosis in infants with Beckwith-Wiedeman syndrome and hepatic anomalies.
- Further research may elucidate the underlying mechanisms connecting these conditions.
Abstract:
Mesothelial inclusion cysts are rare benign tumors not frequently reported in the literature. When reported, they are primarily found in adults. One report from 2006 reports an association with Beckwith-Weideman syndrome, but no other reported cases discuss this correlation. We describe a case of an infant with Beckwith-Weideman syndrome who, in the setting of omphalocele repair, was found to have hepatic cysts with pathology revealing mesothelial inclusion cysts.
