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Updated: Aug 5, 2025

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Development and Validation of a Mixed-Reality Simulator for Reducing Biopsy Core Deviation During Simulated Freehand
Samsun Lampotang1, David E Lizdas, William T Johnson
1From the Center for Safety, Simulation & Advanced Learning Technologies (S.L., D.E.L., W.T.J., V.M., J.W., A.D., Y.A., L.M., W.B. T.S.), Office of Educational Affairs/Office of Medical Education (S.L., A.D.), Department of Anesthesiology (S.L., D.E.L., W.T.J., V.M., J.W., A.D., Y.A., L.M., W.B., T.S.), Clinical & Translational Science Institute (S.L.), and Department of Urology (L.M., W.B., T.S.), University of Florida College of Medicine, Gainesville, FL; Department of Biostatistics (X.L.), University of Florida College of Public Health and Health Professions, Gainesville, FL; Department of Emergency Medicine (Y.A.), University of Health Sciences, Gulhane School of Medicine, Ankara, Turkey; Division of Urology, Department of Surgery (A.A.), University of Toronto, Toronto, Canada.
A new mixed-reality simulator improved prostate biopsy (PBx) accuracy for residents by reducing core deviation. This technology enhances training for systematic prostate biopsy (sPBx), potentially improving clinical outcomes and reducing missed lesions.
Area of Science:
- Medical Simulation
- Urology
- Surgical Training
Background:
- Development of a novel mixed-reality simulator for prostate biopsy (PBx).
- Simulator incorporates real-time 3D visualization and integrated guidance aids.
Purpose of the Study:
- To evaluate the effectiveness of a mixed-reality PBx simulator in improving procedural accuracy.
- To assess the impact of simulator training on urology resident and attending performance.
Main Methods:
- One-on-one training sessions using the simulator for freehand, transrectal ultrasound-guided systematic prostate biopsy (sPBx).
- Baseline and post-training assessments of biopsy core deviation were compared.
- Participants included 24 urology residents and 4 attendings.
Main Results:
- Residents showed a significant decrease in mean core deviation post-training (13.4 mm to 8.7 mm, P < 0.001).
- Attendings demonstrated no significant change in deviation post-training (8.5 mm to 7.6 mm, P = 0.093).
- Novice confidence in performing PBx increased significantly after training (P = 0.011).
Conclusions:
- The mixed-reality PBx simulator effectively quantifies and enhances accuracy in simulated freehand sPBx.
- Improved accuracy may lead to more uniform biopsy core distribution in clinical practice.
- This could reduce the risk of missed prostate cancer lesions and expedite treatment initiation.

