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INTRAVITREAL METHOTREXATE IN VEMURAFENIB-INDUCED UVEITIS.
Artémise Dugauquier1, Ahmad Hussein Awada2, Elie Motulsky3
1Department of Ophthalmology, Erasme Hospital, Brussels, Belgium.
Retinal Cases & Brief Reports
|March 28, 2023
Summary
Vemurafenib, a BRAF inhibitor, can cause severe uveitis, an eye inflammation. A case report shows intravitreal methotrexate injections effectively treated unilateral, severe uveitis when steroids were contraindicated.
Area of Science:
- Ophthalmology
- Oncology
- Pharmacology
Background:
- Vemurafenib is a BRAF inhibitor used for late-stage melanoma.
- Adverse effects of vemurafenib, including ocular complications, are a growing concern.
- Uveitis is a known, though generally manageable, side effect of vemurafenib therapy.
Observation:
- This case report details a patient experiencing unilateral, severe uveitis.
- Conventional topical corticosteroid therapy was contraindicated for this patient.
- The patient's severe uveitis fully recovered following treatment.
Findings:
- Intravitreal methotrexate injections proved effective in treating severe, unilateral vemurafenib-induced uveitis.
- This case highlights a unique presentation and management of vemurafenib-induced uveitis.
- Risk factors and mechanisms underlying vemurafenib-induced uveitis remain largely unknown.
Implications:
- Clinicians must be aware of potentially sight-threatening ocular side effects associated with BRAF inhibitors like vemurafenib.
- Intravitreal methotrexate may be a viable treatment option for severe cases of targeted agent-induced uveitis.
- Further research is needed to understand the risk factors and pathogenesis of vemurafenib-induced uveitis.
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