Multiple micromeningiomas coexist with primary lung adenocarcinoma: A case report

Area of Science:

• Pulmonology
• Oncology
• Pathology

Background:

• Multiple ectopic meningiomas in the lung are exceptionally rare, often clinically indistinguishable from lung cancer on imaging.
• Distinguishing these lesions poses significant diagnostic and therapeutic challenges.

Observation:

• A 65-year-old female presented with multiple bilateral pulmonary nodules.
• Surgical resection revealed a unique combination of pulmonary meningioma, atypical adenomatoid hyperplasia (AAH), carcinoma in situ (AIS), and invasive adenocarcinoma within the nodules.

Findings:

• This case represents the first reported instance of multiple distinct pathological types, including meningioma and various stages of lung adenocarcinoma, occurring simultaneously within pulmonary nodules in a single organ.
• The coexistence of these diverse pathologies underscores the complexity of differential diagnosis in cases of multiple lung nodules.

Implications:

• The findings highlight the critical need for advanced diagnostic modalities and tailored treatment strategies when encountering multiple pulmonary nodules with heterogeneous pathological findings.
• This unique presentation necessitates a re-evaluation of diagnostic criteria and therapeutic approaches for rare pulmonary lesions.