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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
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Multifunctional Layered Double Hydroxides for Drug Delivery and Imaging
Seungjin Yu1,2, Goeun Choi1,2,3, Jin-Ho Choy2,4,5,6
1Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea.
Nanomaterials (Basel, Switzerland)
|March 29, 2023
Summary
Layered double hydroxides (LDHs) are versatile nanomaterials for biomedical applications. This review covers their synthesis, therapeutic actions, and targeting properties for drug delivery and bio-imaging.
Area of Science:
- Biomedical Nanotechnology
- Materials Science
Background:
- Two-dimensional nanomaterials, especially layered double hydroxides (LDHs), offer biocompatibility, biodegradability, and controlled release for biomedical uses.
- LDHs have been explored for drug delivery and imaging since 1999, with recent focus on multifunctional systems.
Purpose of the Study:
- To review synthetic strategies for LDH-based nanohybrids.
- To summarize in-vivo and in-vitro therapeutic actions and targeting properties.
- To highlight recent (2019-2023) multifunctional LDH systems for drug delivery and bio-imaging.
Main Methods:
- Literature review of studies on LDH nanohybrids.
- Analysis of synthetic approaches.
- Evaluation of therapeutic and imaging applications.
Main Results:
- LDHs exhibit favorable properties for biomedical applications.
- Single-function LDH nanohybrids have established applications.
- Multifunctional LDH systems show promise for advanced drug delivery and bio-imaging.
Conclusions:
- LDH nanohybrids are effective platforms for drug delivery and bio-imaging.
- Ongoing research focuses on developing sophisticated multifunctional LDH systems for enhanced therapeutic outcomes.
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