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Related Experiment Video

Updated: Aug 5, 2025

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
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A New Productive Approach and Formulative Optimization for Curcumin Nanoliposomal Delivery Systems.

Raffaella De Piano1, Diego Caccavo1,2,3, Gaetano Lamberti1,2,3

  • 1Dipartimento di Ingegneria Industriale, Università degli Studi di Salerno, Via Giovanni Paolo II n.132, 84084 Fisciano, Italy.

Pharmaceutics
|March 29, 2023
PubMed
Summary

Novel simil-microfluidic technology enables efficient production of liposomal curcumin, a potent system for cancer therapy and nutraceuticals. This method optimizes curcumin loading and encapsulation for scalable nanoliposome manufacturing.

Keywords:
anticancerantioxidant activitycurcuminnanoliposomesnanotechnologiesnutraceuticalssimil-microfluidic technology

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Area of Science:

  • Pharmaceutical Technology
  • Nanotechnology
  • Natural Product Chemistry

Background:

  • Modern manufacturing increasingly relies on sustainable resource utilization and technological advancements.
  • Liposomal curcumin holds promise for cancer therapies and nutraceutical applications due to its therapeutic potential.
  • Existing methods for liposome production face challenges in scalability and efficiency.

Purpose of the Study:

  • To investigate the use of simil-microfluidic technology for producing liposomal curcumin.
  • To optimize the formulation for enhanced curcumin loading and encapsulation.
  • To address process-related issues like curcumin aggregation during production.

Main Methods:

  • Utilized simil-microfluidic technology based on lipid-ethanol and aqueous phase interdiffusion.
  • Performed studies on liposomal production focusing on curcumin loading.
  • Investigated and elucidated process issues, specifically curcumin aggregations.
  • Optimized formulation parameters to maximize curcumin load.

Main Results:

  • Successfully produced massive quantities of nanometric-scale liposomes using simil-microfluidic technology.
  • Identified and addressed curcumin aggregation issues during the production process.
  • Achieved significant curcumin loads and high encapsulation efficiencies in the nanoliposomes.

Conclusions:

  • Simil-microfluidic technology is a viable and efficient method for large-scale nanoliposomal curcumin production.
  • Optimized process conditions allow for high curcumin loading and encapsulation, suitable for therapeutic and nutraceutical uses.
  • This technology offers a sustainable approach to manufacturing advanced curcumin delivery systems.