Recent progress in the homogeneous gold-catalysed cycloisomerisation reactions
Mahender Kumar1,2, Kajal Kaliya1,2, Sushil K Maurya3
1Chemical Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176 061, HP, India.
Organic & Biomolecular Chemistry
|March 29, 2023
Summary
Gold catalysis enables efficient synthesis of complex polycyclic molecules from ynamides, diynes, and enynes. This review highlights gold-catalyzed cycloisomerization reactions for creating diverse chemical structures in a single step.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Chemistry
Background:
- Gold catalysis has gained significant attention in the last two decades.
- Gold complexes effectively activate unsaturated groups and tolerate diverse functional groups.
Purpose of the Study:
- To review gold-catalyzed cycloisomerization reactions involving ynamides, diynes, and 1,n-enynes.
- To showcase the synthetic utility of these reactions for generating complex polycyclic compounds.
Main Methods:
- Summarization of literature on gold-catalyzed cycloisomerization reactions.
- Focus on reactions involving ynamides, diynes, and 1,n-enynes.
Main Results:
- Gold-catalyzed cycloisomerization provides a versatile route to various complex chemical structures.
- Efficient synthesis of fused spiro carbocycles, BODIPY cores, bicyclo[3.2.1]oct-2-ene, dihydro benzo[b]thiepine, disubstituted furans, spiroindolines, and bridged [n.2.1] skeletons is demonstrated.
Conclusions:
- Gold-catalyzed cycloisomerization reactions offer powerful opportunities for one-step synthesis of intricate polycyclic moieties.
- This methodology is valuable for accessing a wide array of complex organic molecules.
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