Related Experiment Video

Updated: Aug 4, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
06:07

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Published on: August 5, 2022

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Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14

Chi Zhang, Luiza Tunes, Meng-Hsiung Hsieh

    Biorxiv : the Preprint Server for Biology
    |March 30, 2023
    PubMed
    Summary

    A cancer-associated mutation in METTL14 (METTL14R298P) alters N6-methyladenosine (m6A) RNA modification sites, promoting cancer growth by targeting noncanonical GGAU motifs. This highlights the importance of m6A site specificity in gene regulation and oncogenesis.

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