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    The adder cell size control strategy offers an advantage for growing populations facing mortality. This benefit arises from epigenetic heritability, allowing populations to adapt to varying mortality risks.

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    Area of Science:

    • Cellular biology
    • Population dynamics
    • Evolutionary mechanisms

    Background:

    • Cell size regulation is crucial for cellular function and proliferation.
    • Growing cell populations face mortality risks influenced by cell size.
    • Existing models explore various cell size control mechanisms.

    Purpose of the Study:

    • To analyze the advantage of cell size control strategies in growing populations under mortality constraints.
    • To determine the efficacy of the adder control strategy against growth-dependent and size-dependent mortality.
    • To elucidate the role of epigenetic heritability in cell size adaptation.

    Main Methods:

    • Mathematical modeling of cell populations with different size control strategies.
    • Analysis of growth-dependent and size-dependent mortality functions.
    • Simulation of population dynamics under varying mortality landscapes.

    Main Results:

    • The adder control strategy demonstrates a general advantage in populations with growth-dependent mortality.
    • This advantage persists across diverse size-dependent mortality landscapes.
    • Epigenetic heritability of cell size is identified as a key factor enabling adaptation.

    Conclusions:

    • The adder strategy provides a robust mechanism for navigating mortality thresholds in growing cell populations.
    • Epigenetic heritability of cell size facilitates adaptive evolution by allowing selection to act on size distributions.
    • Cell size control strategies are critical for population survival and adaptation in dynamic environments.