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Increased Plasma Homocysteine Levels Are Associated with Left Ventricular Hypertrophy in Hypertensive Patients with

Lingyu Zhang1,2,3,4, Tingjun Wang5,6,7,8, Yihua Shen6,7,8,9

  • 1Department of General Practice, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China, fjykdxzly@163.com.

Kidney & Blood Pressure Research
|March 30, 2023
PubMed

Insights

Plasma homocysteine levels are linked to left ventricular hypertrophy (LVH) in hypertensive individuals with normal kidney function. Higher homocysteine correlates with increased LVMI and LVH risk in this specific patient group.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Clinical Biochemistry

Background:

  • Renal function significantly impacts plasma homocysteine levels.
  • Plasma homocysteine is recognized as a risk factor for left ventricular hypertrophy (LVH).
  • The interplay between renal function, homocysteine, and LVH requires further elucidation.

Purpose of the Study:

  • To investigate the associations among left ventricular mass index (LVMI), plasma homocysteine, and renal function.
  • To determine if renal function modifies the relationship between homocysteine and LVH.
  • Study conducted in a southern Chinese population.

Main Methods:

  • Cross-sectional study of 2,464 patients (June 2016 - July 2021).
  • Patients stratified by gender-specific homocysteine tertiles.
  • LVH defined as LVMI ≥115 g/m² (men) or ≥95 g/m² (women).

Main Results:

  • LVMI and LVH prevalence increased significantly with higher homocysteine levels; eGFR decreased.
  • Homocysteine and eGFR were independently associated with LVMI in hypertensive patients.
  • Homocysteine independently associated with LVMI in hypertensive patients with eGFR ≥90 mL/(min·1.73 m²).
  • High homocysteine tertile nearly doubled LVH risk in hypertensive patients with normal eGFR (OR = 2.780).

Conclusions:

  • Plasma homocysteine is independently associated with LVMI in hypertensive patients with normal renal function (eGFR ≥90 mL/(min·1.73 m²)).
  • The association between homocysteine and LVMI is dependent on both hypertension and normal renal function.
Abstract

Keywords:
HomocysteineHypertensionLeft ventricular hypertrophyLeft ventricular mass indexRenal function

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