Sweetened Alkylated Verdazyls Effectively Kill Cancer Cells under Light Irradiation
Darya E Votkina1, Alexander A Abramov1, Ekaterina S Kovalskaya1
1Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk, 634050, Russia.
Abstract:
The development of novel photo-dynamic therapy (PDT) agents enabling to treat the oxygen-deficient tumors is the emerging tasks for the modern medicinal chemistry. Herein, we describe the design and preparation of water-soluble agents for PDT which generate active radical species upon light irradiation. Two conjugates of carbohydrates with 1,2,4,6-substituted-1,4-dihydro-1,2,4,5-tetrazin-3(2H)-ones (AlkVZs) demonstrated high oxygen-independent cytotoxicity on PC-3 and Jurkat cancer cells under light irradiation combining with low toxicity in the dark. The efficacy of prepared compounds was estimated using MTT and Alamar Blue tests as well as microscopic dead/live colored images and flow cytometry. The analysis of obtained results reveals the influence of sugar moiety on the activity of AlkVZs. We believe that obtained compounds have high potency as platform for design of new agents for photo-dynamic therapy.
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