Related Experiment Video
Updated: Aug 4, 2025
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
13.2K
The Confusion Surrounding Androgen Deprivation Therapy and Cognitive Dysfunction.
Michael J Pierro1, Deepak Kilari1
1Division of Hematology/Oncology, Department of Internal Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.
European Urology Focus
|April 2, 2023
Summary
Androgen deprivation therapy (ADT) for prostate cancer may be linked to cognitive decline. This research examines long-term ADT use, other treatments, and genetic factors influencing this association.
Area of Science:
- Oncology
- Neuroscience
- Genetics
Background:
- Androgen deprivation therapy (ADT) is a common prostate cancer treatment.
- Emerging evidence suggests a potential link between ADT and cognitive decline.
- The impact of chronic ADT and other systemic treatments on cognition requires further investigation.
Purpose of the Study:
- To explore the association between chronic androgen deprivation therapy (ADT) and cognitive decline.
- To investigate the role of other systemic prostate cancer treatments in cognitive function.
- To examine the influence of genetic polymorphisms on ADT-related cognitive changes.
Main Methods:
- Review of existing studies on ADT and cognitive outcomes.
- Analysis of data from patients undergoing chronic ADT.
- Inclusion of studies considering genetic variations and treatment effects.
Main Results:
- Varied associations identified between ADT use and cognitive decline.
- First studies evaluating chronic ADT use and cognitive impact highlighted.
- Exploration of other systemic treatments and genetic factors in this context.
Conclusions:
- The relationship between ADT and cognitive decline is complex and warrants further research.
- Understanding genetic predispositions may help predict cognitive risks.
- Long-term ADT use necessitates careful consideration of potential cognitive side effects.
Related Concept Videos
01:26Alzheimer's Disease: Overview
557
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
557
01:22Alzheimer's Disease: Treatment
232
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
232
01:20Disorders of the Male Reproductive System
491
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
491
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
172
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
172
01:30Cognitive Development During Adulthood
178
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
178
01:30Dementia
150
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
150