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Perspective: Nutrition's Next Chapter - Bioactive Gaps and the Microbiome-Mitochondria Axis
1Department of Medicine, Division of Gastroenterology, University of Washington, Seattle, WA, United States.
Advances in Nutrition (Bethesda, Md.)
|April 3, 2023
Summary
Food
Area of Science:
- Nutritional Science
- Biochemistry
- Human Health
Background:
- Twentieth-century nutrition science focused on macronutrients and micronutrients.
- Modern nutrition science emphasizes bioactive food components.
- The human body's transformation by food is a fundamental concept.
Purpose of the Study:
- To highlight the evolution of nutrition science from basic components to bioactive substances.
- To underscore the role of the microbiome and mitochondria in nutrient utilization.
- To introduce next-generation nutritional strategies for malnutrition.
Main Methods:
- Review of historical and current nutrition research.
- Analysis of the food matrix and its components.
- Exploration of the interplay between diet, microbiome, and mitochondria.
Main Results:
- Bioactive substances (fibers, phytonutrients, etc.) are crucial regulators of bodily transformation.
- The microbiome and mitochondria are key orchestrators of health through bioactives.
- Understanding these interactions informs new approaches to over- and undernutrition.
Conclusions:
- Nutrition science has advanced to recognize the complex roles of bioactive food components.
- Targeting the microbiome and mitochondria offers promising avenues for nutritional interventions.
- Personalized nutrition strategies are emerging to address global malnutrition challenges.
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