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Pediatric reference values for calcium, magnesium and inorganic phosphorus in serum obtained from Bhattacharya plots

W de Kieviet, E H Slaats, N G Abeling

    Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Fur Klinische Chemie Und Klinische Biochemie
    |April 1, 1986
    PubMed

    Insights

    This study provides pediatric reference ranges for total calcium, magnesium, and inorganic phosphorus. These values are essential for accurate clinical interpretation in children and adolescents.

    Area of Science:

    • Clinical Biochemistry
    • Pediatric Laboratory Medicine

    Background:

    • Accurate pediatric reference values are crucial for diagnosing metabolic and endocrine disorders.
    • Existing reference ranges may not adequately reflect current pediatric populations.

    Purpose of the Study:

    • To establish reliable pediatric reference values for total calcium, magnesium, and inorganic phosphorus.
    • To assess the age-dependency of these electrolyte concentrations in children.

    Main Methods:

    • Utilized Bhattacharya plots for data analysis of unselected patient values.
    • Analyzed large datasets for total calcium (n=8320), magnesium (n=1231), and inorganic phosphorus (n=3349).

    Main Results:

    • Pediatric reference ranges for calcium (2.14-2.64 mmol/l) and magnesium (0.57-1.12 mmol/l) showed minimal age-related variation up to 20 years.
    • Inorganic phosphorus concentrations demonstrated a significant decrease with age, from 1.56-2.29 mmol/l (infants <1 year) to 1.03-1.78 mmol/l (children >15 years).

    Conclusions:

    • Established age-specific reference intervals for key electrolytes in pediatric populations.
    • Highlights the distinct age-related decline in inorganic phosphorus compared to calcium and magnesium.

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