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Updated: Aug 4, 2025

Four-Dimensional CT Analysis Using Sequential 3D-3D Registration
Published on: November 23, 2019
Density-adaptive registration of pointclouds based on Dirichlet Process Gaussian Mixture Models
Tingting Jia1,2, Zeike A Taylor3, Xiaojun Chen4,5
1School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China.
Abstract:
We propose an algorithm for rigid registration of pre- and intra-operative patient anatomy, represented as pointclouds, during minimally invasive surgery. This capability is essential for development of augmented reality systems for guiding such interventions. Key challenges in this context are differences in the point density in the pre- and intra-operative pointclouds, and potentially low spatial overlap between the two. Solutions, correspondingly, must be robust to both of these phenomena. We formulated a pointclouds registration approach which considers the pointclouds after rigid transformation to be observations of a global non-parametric probabilistic model named Dirichlet Process Gaussian Mixture Model. The registration problem is solved by minimizing the Kullback-Leibler divergence in a variational Bayesian inference framework. By this means, all unknown parameters are recursively inferred, including, importantly, the optimal number of mixture model components, which ensures the model complexity efficiently matches that of the observed data. By presenting the pointclouds as KDTrees, both the data and model are expanded in a coarse-to-fine style. The scanning weight of each point is estimated by its neighborhood, imparting the algorithm with robustness to point density variations. Experiments on several datasets with different levels of noise, outliers and pointcloud overlap show that our method has a comparable accuracy, but higher efficiency than existing Gaussian Mixture Model methods, whose performance is sensitive to the number of model components.
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