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Updated: Aug 4, 2025

Deep and Spatially Controlled Volume Ablations using a Two-Photon Microscope in the Zebrafish Gastrula
Published on: July 15, 2021
Topography-guided excimer laser ablation
Alex C Onishi1, Calisa Lee-Choi2, Amir H Marvasti1,2
1Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine at the University of California, Los Angeles.
Purpose Of Review:
Currently, the most commonly performed corneal refractive surgery is laser-assisted in-situ keratomileusis (LASIK). Customized forms of LASIK have been developed, which have allowed for improved outcomes and the enhanced correction of higher order aberrations (HOAs). This review discusses one form of custom LASIK, topography-guided LASIK, including factors involved in preoperative planning, and advantages and disadvantages compared with other forms of keratorefractive surgery.
Recent Findings:
Various treatment-planning approaches addressing discrepancies between the refractive and topographic astigmatic magnitude and axis have been used successfully, although there is debate regarding a superior method in the literature.
Summary:
There are many forms of custom LASIK, which provide excellent outcomes. Topography-guided LASIK may be of particular use in highly aberrated corneas and may also provide outstanding outcomes in healthy eyes given its emphasis on treating the primary refractive surface of the eye.

