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Updated: Aug 4, 2025

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics
Published on: July 23, 2020
The possibility of anesthesia stimulated by a train of current pulses
Mikhail N Shneider1, Mikhail Pekker2
1Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ, United States of America.
Abstract:
This study considers a simple theoretical model of blocking the passage of signals (action potentials) from sensory neurons, thereby affecting anesthesia without the use of anesthetics as a result of a sequence of unipolar current pulses generated by an external source. The proposed model allows the selection of parameters and the required frequency of the repetition of current pulses for the possible implementation of anesthesia, depending on the electrical characteristics of the skin and the conductivity of the saline solution in which the myelinated nerve fibers are located.
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