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Practical evaluation of a warm-reactive anti-M
X Yang1, J M Syrjamaki2, P A Ruegsegger3
1MD, PhD, Resident Physician, Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, 600 Highland Avenue, Madison, WI 53792, US.
Immunohematology
|April 5, 2023
Summary
This study details a rare case of warm-reactive Anti-M, an antibody against the M antigen in the MNS blood group system. Identifying this clinically significant antibody required specific investigational methods.
Area of Science:
- Immunology
- Transfusion Medicine
- Blood Banking
Background:
- Anti-M is typically a cold-reactive antibody against the M antigen in the MNS blood group system.
- Usually, Anti-M is clinically insignificant due to its poor reactivity at 37°C.
- Rare instances of warm-reactive Anti-M, which can cause transfusion reactions, have been documented.
